Adoptive immunotherapy
نویسندگان
چکیده
منابع مشابه
Adoptive immunotherapy
T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development ...
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Modified T cells that have been engineered to recognize the CD19 surface marker have recently been shown to be very successful at treating acute lymphocytic leukemias. Here we explore four previous approaches that have used ordinary differential equations to the model this type of therapy, compare their properties, and modify the models to address their deficiencies. Although the four models tr...
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The standard front-line therapy for epithelial ovarian cancer (EOC) is combination of debulking surgery and platinum-based chemotherapy. Nevertheless, the majority of patients experience disease recurrence. Although extensive efforts to find new therapeutic options, cancer cells invariably develop drug resistance and disease progression. New therapeutic strategies are needed to improve prognosi...
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Adoptive immunotherapy is an attractive and elegant strategy for treating a variety of life-threatening diseases. Several approaches have been developed to generate antigen-specific CD4+ and CD8+ T cells for adoptive T-cell therapy in cancer and infectious diseases. Currently, many approaches are based on either the use of autologous peptide pulsed dendritic cells as antigen-presenting cells or...
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Recent publications from this laboratory (1, 2) have shown that it is possible to cause the regression of established immunogenic murine tumors by the passive transfer of tumor-sensitized T cells from immunized donors, provided the tumor-bearing recipients have been made T cell-deficient by thymectomy and irradiation. The need for T cell-deficient tumor-bearing recipients to demonstrate success...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2013
ISSN: 2162-402X
DOI: 10.4161/onci.26199